Unveiling the Chemical Structure and Properties of Methylone


Methylone, also known as 3,4-methylenedioxy-N-methylcathinone, is a synthetic cathinone derivative with psychoactive properties. Understanding its chemical structure and properties is crucial for assessing its pharmacological effects and potential risks associated with its use.

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Chemical Structure:

  • Chemical Formula: C<sub>11</sub>H<sub>13</sub>NO<sub>3</sub>
  • Molar Mass: 207.23 g/mol
  • Structural Features: Methylone belongs to the substituted cathinone class, characterized by a β-keto moiety and a phenethylamine backbone substituted with a methylenedioxy functional group.

Physicochemical Properties:

  • Physical State: Typically appears as a white crystalline powder
  • Melting Point: Approximately 182-184°C
  • Solubility: Soluble in organic solvents such as ethanol and acetone; sparingly soluble in water

Pharmacological Effects:

Methylone acts as a releasing agent of serotonin, dopamine, and norepinephrine, resulting in stimulating and empathogenic effects similar to those of MDMA (ecstasy). It induces feelings of euphoria, increased sociability, and heightened sensory perception in users. However, it also poses risks of adverse effects such as tachycardia, hypertension, hyperthermia, and serotonin syndrome, especially at higher doses or in combination with other substances.

Legislation and Regulation:

Due to its psychoactive properties and potential for abuse, methylone is classified as a controlled substance in many countries. Its manufacture, distribution, and possession are subject to legal restrictions and regulations aimed at preventing its misuse and safeguarding public health.


Methylone, with its distinctive chemical structure and pharmacological effects, represents a significant subject of study in the field of psychopharmacology. Understanding its properties, mechanisms of action, and associated risks is essential for informed decision-making regarding its regulation, medical use, and harm reduction strategies. Continued research into its pharmacology, toxicology, and potential therapeutic applications will contribute to a comprehensive understanding of its impact on human health and society.

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